Serveur d'exploration sur la maladie de Parkinson

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Distinct patterns of regional cerebral glucose metabolism in Parkinson's disease with and without mild cognitive impairment

Identifieur interne : 000B13 ( Main/Exploration ); précédent : 000B12; suivant : 000B14

Distinct patterns of regional cerebral glucose metabolism in Parkinson's disease with and without mild cognitive impairment

Auteurs : Yoshiyuki Hosokai [Japon] ; Yoshiyuki Nishio [Japon] ; Kazumi Hirayama [Japon] ; Atsushi Takeda [Japon] ; Toshiyuki Ishioka [Japon] ; Yoichi Sawada [Japon] ; Kyoko Suzuki [Japon] ; Yasuto Itoyama [Japon] ; Shoki Takahashi [Japon] ; Hiroshi Fukuda [Japon] ; Etsuro Mori [Japon]

Source :

RBID : ISTEX:919F26ADE6703F3E1214C9571837BF559B889491

English descriptors

Abstract

There is no consensus with regard to the clinical and neuroimaging characteristics of prodromal dementia in Parkinson's disease (PD). To delineate functional neuroimaging features of PD with mild cognitive impairment (PDMCI) and with no cognitive impairment (PDNC), we compared regional cerebral glucose metabolism (CMRglc) amongst 13 patients with PDMCI, 27 with PDNC, and 13 healthy controls. The PDNC patients had limited areas of hypometabolism in the frontal and occipital cortices. In the PDMCI patients, there were extensive areas of hypometabolism in the posterior cortical regions, including the temporo‐parieto‐occipital junction, medial parietal, and inferior temporal cortices. The present results suggest that posterior cortical dysfunction is the primary neuroimaging feature of PD patients at risk for dementia. © 2009 Movement Disorder Society

Url:
DOI: 10.1002/mds.22444


Affiliations:


Links toward previous steps (curation, corpus...)


Le document en format XML

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<div type="abstract" xml:lang="en">There is no consensus with regard to the clinical and neuroimaging characteristics of prodromal dementia in Parkinson's disease (PD). To delineate functional neuroimaging features of PD with mild cognitive impairment (PDMCI) and with no cognitive impairment (PDNC), we compared regional cerebral glucose metabolism (CMRglc) amongst 13 patients with PDMCI, 27 with PDNC, and 13 healthy controls. The PDNC patients had limited areas of hypometabolism in the frontal and occipital cortices. In the PDMCI patients, there were extensive areas of hypometabolism in the posterior cortical regions, including the temporo‐parieto‐occipital junction, medial parietal, and inferior temporal cortices. The present results suggest that posterior cortical dysfunction is the primary neuroimaging feature of PD patients at risk for dementia. © 2009 Movement Disorder Society</div>
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